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Ehlers-Danlos Syndrome

A group of heritable connective tissue disorders

Ehlers-Danlos Syndrome (EDS) is a group of heritable connective tissue disorders characterized by joint hypermobility, skin extensibility, and tissue fragility. There are 13 subtypes, with hypermobile EDS (hEDS) being the most common and frequently co-occurring with POTS and MCAS.

Types & Subtypes

Hypermobile EDS (hEDS)

Most common; joint hypermobility, chronic pain, fatigue

Classical EDS

Skin hyperextensibility, fragile skin, joint hypermobility

Vascular EDS

Arterial/organ rupture risk; most severe subtype

Kyphoscoliotic EDS

Progressive scoliosis and muscle weakness

Common Symptoms

Joint hypermobilityChronic painFrequent dislocationsStretchy skinFatigueDysautonomiaGI problemsAnxietyPoor wound healingEasy bruising

Management & Treatment Options

Physical therapy
Proprioception training
Bracing/splinting
Pain management
Low-impact exercise
Occupational therapy
Vitamin C supplementation
Addressing comorbidities

⚠️ Always consult a healthcare provider before starting any treatment.

Trusted Resources

🔗 The Ehlers-Danlos Society🔗 HMSA (Hypermobility Syndromes Association)

Knowledge Base

6 documents

Sourced from authoritative medical organizations and peer-reviewed research.

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Genetic Variants

GWAS Research
See all variants →

Top genetic variants associated with EDS in published genome-wide association studies.

rs28357094

TNXB

Extracellular Matrix

OR 4.12

p=8.9e-18

rs1800255

COL3A1

Connective tissue / ECM

OR

p=1.0e-15

rs35068180

TNXB

Connective tissue / ECM

OR 2.31

p=8.7e-11

⚠️ Genetic associations do not determine diagnosis. Consult a genetic counselor.

Upload 23andMe →

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