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Irritable Bowel Syndrome (IBS)

A functional GI disorder causing chronic abdominal pain and altered bowel habits

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder affecting the large intestine. It affects 10–15% of the global population and is one of the most common GI conditions seen by physicians. IBS frequently co-occurs with dysautonomia, MCAS, fibromyalgia, and anxiety disorders, suggesting shared underlying mechanisms.

Types & Subtypes

IBS-C

Constipation-predominant

IBS-D

Diarrhea-predominant

IBS-M

Mixed constipation and diarrhea

Post-Infectious IBS

Triggered by GI infection

Common Symptoms

Abdominal painBloatingGasDiarrheaConstipationMucus in stoolUrgencyIncomplete evacuationFatigueAnxiety

Management & Treatment Options

Low-FODMAP diet
Fiber supplementation
Antispasmodics
Loperamide
Rifaximin
Low-dose tricyclic antidepressants
SSRIs
Cognitive behavioral therapy
Gut-directed hypnotherapy
Probiotics

⚠️ Always consult a healthcare provider before starting any treatment.

Trusted Resources

🔗 International Foundation for GI Disorders🔗 IBS Network

Knowledge Base

6 documents

Sourced from authoritative medical organizations and peer-reviewed research.

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Genetic Variants

GWAS Research
See all variants →

Top genetic variants associated with IBS in published genome-wide association studies.

rs6554199

SCN10A

Ion channel

OR 1.28

p=3.4e-8

rs4795541

SLC6A4

Serotonin signaling

OR 1.31

p=4.2e-8

rs1042779

HTR3A

Serotonin signaling

OR 1.24

p=7.8e-7

⚠️ Genetic associations do not determine diagnosis. Consult a genetic counselor.

Upload 23andMe →

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