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Long COVID / Post-Acute Sequelae of SARS-CoV-2

Persistent symptoms lasting weeks or months after COVID-19 infection

Long COVID (also called Post-Acute Sequelae of SARS-CoV-2 or PASC) refers to a wide range of new, returning, or ongoing health problems that people experience after first being infected with SARS-CoV-2. It affects an estimated 65 million people globally.

Types & Subtypes

Post-COVID Dysautonomia

Autonomic dysfunction triggered by COVID-19 infection

Post-COVID MCAS

Mast cell activation triggered or worsened by COVID-19

Post-COVID ME/CFS

Chronic fatigue syndrome following COVID-19

Post-COVID Cognitive Impairment

Brain fog, memory issues, and cognitive difficulties

Common Symptoms

FatigueBrain fogPost-exertional malaiseShortness of breathHeart palpitationsChest painJoint painSleep disturbancesAnxiety/depressionSmell/taste changes

Management & Treatment Options

Pacing and energy management
Antihistamines for MCAS
Low-dose naltrexone
Anticoagulation therapy
Pulmonary rehabilitation
Cognitive rehabilitation
Autonomic nervous system support

⚠️ Always consult a healthcare provider before starting any treatment.

Trusted Resources

🔗 Long COVID Alliance🔗 Patient-Led Research Collaborative

Knowledge Base

6 documents

Sourced from authoritative medical organizations and peer-reviewed research.

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Genetic Variants

GWAS Research
See all variants →

Top genetic variants associated with Long COVID in published genome-wide association studies.

rs3131379

STAT4

Interferon Signaling

OR 1.37

p=1.9e-6

rs1799945

HFE

Iron Metabolism

OR 1.31

p=3.6e-5

rs2230054

ACE2

Renin-Angiotensin System

OR 1.19

p=4.4e-5

⚠️ Genetic associations do not determine diagnosis. Consult a genetic counselor.

Upload 23andMe →

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