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Mast Cell Activation Syndrome
When mast cells release too many chemical mediators
Mast Cell Activation Syndrome (MCAS) is a condition in which mast cells inappropriately and excessively release chemical mediators, resulting in a range of chronic multisystem polymorphic symptoms. MCAS frequently co-occurs with POTS, EDS, and Long COVID.
Types & Subtypes
Primary MCAS
Caused by clonal mast cell disorders
Secondary MCAS
Triggered by another underlying condition
Idiopathic MCAS
No identifiable underlying cause
Common Symptoms
Skin flushingHives/urticariaAnaphylaxisAbdominal painNausea/vomitingDiarrheaBrain fogFatigueBone painHeadaches
Management & Treatment Options
H1 antihistamines
H2 antihistamines
Mast cell stabilizers (cromolyn)
Quercetin
Low-histamine diet
Epinephrine auto-injector
Omalizumab
Aspirin (in some cases)
⚠️ Always consult a healthcare provider before starting any treatment.
Trusted Resources
Knowledge Base
6 documentsSourced from authoritative medical organizations and peer-reviewed research.
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