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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome

A serious, long-term illness affecting multiple body systems

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a serious, long-term illness that affects many body systems. People with ME/CFS are often not able to do their usual activities. The hallmark symptom is post-exertional malaise (PEM) — a worsening of symptoms after physical or mental exertion.

Types & Subtypes

Classic ME/CFS

Meets full diagnostic criteria with PEM as hallmark

Post-Viral ME/CFS

Triggered by viral infection (including COVID-19)

Pediatric ME/CFS

Affects children and adolescents

Common Symptoms

Post-exertional malaise (PEM)Profound fatigueUnrefreshing sleepCognitive impairment (brain fog)Orthostatic intolerancePainSensory sensitivitiesImmune dysfunctionGI problemsTemperature dysregulation

Management & Treatment Options

Pacing and energy management
Heart rate monitoring
Sleep hygiene
Pain management
Low-dose naltrexone
Treating comorbidities
Avoiding overexertion
Cognitive pacing

⚠️ Always consult a healthcare provider before starting any treatment.

Trusted Resources

🔗 ME Action🔗 Solve ME/CFS Initiative🔗 Open Medicine Foundation

Knowledge Base

6 documents

Sourced from authoritative medical organizations and peer-reviewed research.

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Genetic Variants

GWAS Research
See all variants →

Top genetic variants associated with ME/CFS in published genome-wide association studies.

rs3087456

TRPM3

Ion Channel Function

OR 1.51

p=7.3e-8

rs2070729

NRXN3

Neurological Function

OR 1.34

p=2.8e-6

⚠️ Genetic associations do not determine diagnosis. Consult a genetic counselor.

Upload 23andMe →

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