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Sjögren's Syndrome

An autoimmune disease causing dryness, fatigue, and systemic inflammation

Sjögren's syndrome is a systemic autoimmune disease that affects the entire body. Along with symptoms of extensive dryness, other serious complications include profound fatigue, chronic pain, major organ involvement, neuropathies, and lymphomas. It affects approximately 4 million Americans, 90% of whom are women.

Types & Subtypes

Primary Sjögren's

Occurs alone without another autoimmune disease

Secondary Sjögren's

Occurs alongside another autoimmune condition like lupus or RA

Common Symptoms

Dry eyesDry mouthFatigueJoint painSwollen salivary glandsSkin rashesVaginal drynessPeripheral neuropathyBrain fogAutonomic dysfunction

Management & Treatment Options

Artificial tears and saliva substitutes
Hydroxychloroquine
Pilocarpine
Cevimeline
NSAIDs
Immunosuppressants
Rituximab for severe cases
Dental care

⚠️ Always consult a healthcare provider before starting any treatment.

Trusted Resources

🔗 Sjögren's Foundation🔗 Sjögren's Syndrome Foundation UK

Knowledge Base

6 documents

Sourced from authoritative medical organizations and peer-reviewed research.

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Genetic Variants

GWAS Research
See all variants →

Top genetic variants associated with Sjögren's in published genome-wide association studies.

rs2856674

HLA-DQB1

Antigen presentation (HLA)

OR 3.53

p=8.0e-114

rs10516487

BLK

B cell signaling

OR 1.44

p=3.2e-12

⚠️ Genetic associations do not determine diagnosis. Consult a genetic counselor.

Upload 23andMe →

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