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Small Fiber Neuropathy (SFN)

Damage to the small nerve fibers causing pain and autonomic symptoms

Small Fiber Neuropathy (SFN) is a condition caused by damage to the small nerve fibers that carry pain and temperature signals and control autonomic functions. It frequently co-occurs with POTS, MCAS, and EDS, and is increasingly recognized as a contributor to dysautonomia symptoms.

Types & Subtypes

Idiopathic SFN

No identifiable cause; most common form

Autoimmune SFN

Caused by autoimmune attack on small nerve fibers

Metabolic SFN

Associated with diabetes, pre-diabetes, or thyroid disease

Hereditary SFN

Genetic mutations (SCN9A, SCN10A, SCN11A)

Common Symptoms

Burning pain in feet/handsNumbness and tinglingAllodynia (pain from light touch)Autonomic dysfunctionDry eyes/mouthBladder dysfunctionSweating abnormalitiesGI dysmotility

Management & Treatment Options

Pain management (gabapentin, duloxetine)
Low-dose naltrexone
IVIG (for autoimmune SFN)
Alpha-lipoic acid
Topical treatments (lidocaine, capsaicin)
Addressing underlying cause
Lifestyle modifications

⚠️ Always consult a healthcare provider before starting any treatment.

Trusted Resources

🔗 Foundation for Peripheral Neuropathy🔗 NORD – Small Fiber Neuropathy

Knowledge Base

6 documents

Sourced from authoritative medical organizations and peer-reviewed research.

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